| Date | Location | Result | |
| 02-18-06 | Salem Civic Center (Salem, VA) | Hampden-Sydney 68, Roanoke 58 | Box score |
| 02-14-06 | Salem, VA | Emory & Henry 115, Roanoke 101 | Box score |
| 02-11-06 | Ragan-Brown Field House (Greensboro, NC) | Roanoke 84, Guilford 73 | Box score |
| 02-08-06 | Salem, VA | Roanoke 68, Bridgewater 54 | Box score |
| 02-06-06 | Hampden-Sydney, VA | Hampden-Sydney 62, Roanoke 53 | Box score |
| 02-04-06 | Lynchburg, VA | Roanoke 66, Lynchburg 54 | Box score |
| 02-01-06 | Emory, VA | Emory & Henry 103, Roanoke 100 | Box score |
| 01-28-06 | Salem, VA | Roanoke 62, Washington and Lee 46 | Box score |
| 01-25-06 | Harrisonburg, VA | Eastern Mennonite 86, Roanoke 79 | Box score |
| 01-22-06 | Batten Center/Virginia Beach, VA | Virginia Wesleyan 72, Roanoke 50 | Box score |
| 01-21-06 | Ashland, VA; Crenshaw Gymnasium | Randolph-Macon 57, Roanoke 56 | Box score |
| 01-15-06 | Salem, VA | Roanoke 58, Lynchburg 44 | Box score |
| 01-14-06 | Salem, VA | Roanoke 72, Hampden-Sydney 63 | Box score |
| 01-11-06 | Salem, VA | Guilford 71, Roanoke 53 | Box score |
| 01-07-06 | Lexington, Va. (Warner Center) | Washington and Lee 76, Roanoke 70 | Box score |
| 01-04-06 | Salem, VA | Roanoke 73, Ferrum 66 | Box score |
| 01-03-06 | Salem, VA | UMass-Dartmouth 87, Roanoke 78 | Box score |
| 12-07-05 | Nininger Hall, Bridgewater VA | Roanoke College 78, Bridgewater 70 | Box score |
| 12-04-05 | Salem, VA | Randolph-Macon 71, Roanoke 61 | Box score |
| 12-03-05 | Salem, VA | Virginia Wesleyan 58, Roanoke 41 | Box score |
| 11-30-05 | Salem, VA | Roanoke 79, Eastern Mennonite 73 | Box score |
| 11-26-05 | Sports & Recreation Center, Towson, Md. | Roanoke 85, N.C. Wesleyan 74 | Box score |
| 11-25-05 | Sports & Recreation Center, Towson, Md. | Roanoke 87, Goucher 76 | Box score |
| 11-22-05 | Ferrum, Va. (Swartz Gymnasium) | Roanoke 72, Ferrum 68 | Box score |
| 11-20-05 | Salem, VA | Roanoke 68, Ithaca 64 | Box score |
| 11-19-05 | Salem, VA | Roanoke 71, Springfield 69 | Box score |